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"It was Seinfeld, with Larry David, who mainstreamed misanthropy with his eponymous sit-com."

This is a really good point that bears repeating. Seinfeld, at least to me, was the original show where you never really liked any of the main characters. A lot of shows that came after were built on the same or a similar premise.

Also it should be noted that Larry David has enjoyed pretty durable success taking that premise and running with it to an absurd degree. Ditto Julia Louis-Dreyfus in VEEP.

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